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SharePoint 2010 - Excel Documents no longer opening for all users

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We have been using SharePoint 2010 for some time now and have built out a Shared Document Library for all end users to access frequently used documents for all clients.  Up until this past week, all documents (Word, Excel, PowerPoint, etc.) were able to be opened and edited and then resaved to the client profile.  All documents continue to open with the exception of all Excel documents. It gives the error message of "Unable to Process Request". We are using SharePoint 2010, all users are on Office 2010, and everyone is opening SharePoint using Internet Explorer.  Any additional suggestions or thoughts are appreciated and welcome. 


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